Immunotherapy in allergy and cellular tests: state of art.

The basophil activation test (BAT) is an in vitro assay where the activation of basophils upon exposure to various IgE-challenging molecules is measured by flow cytometry. It is a cellular test able to investigate basophil behavior during allergy and allergy immunotherapy. A panoply of critical issues and suggestive advances have rendered this assay a promising yet puzzling tool to endeavor a full comprehension of innate immunity of allergy desensitization and manage allergen or monoclonal anti-IgE therapy. In this review a brief state of art of BAT in immunotherapy is described focusing onto the analytical issue pertaining BAT performance in allergy specific therapy.

Example Template
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4 days ago (13 Oct 25 21:23 UTC)

Below is the JCS template - but feel free to use your own if you'd like
Background, Guidelines, and Further ReadingBriefly outline the current standard of care - current guidelines(URL) or results of notable trials.What gaps does this research intend to address to our current understanding of medical therapy?
Methods and Study DesignType, duration, and location of studySample Size and population

Number of patients assigned to each study arm

Baseline CharacteristicsInclusion CriteriaExclusion CriteriaInterventions Type of statistical analysis (Intent to treat or harm, etc)Outcomes (primary, secondary, subgroup analysis, etc)Funding
ResultsInclude any statistical values and calculate NNT or NNH if applicable

Primary

Secondary

Subgroups

List any notable unintended adverse effects (note: this can make or break many drugs)

CritiqueYour evaluation of this study - strengths and limitations/weaknesses. Clinical impact - can the results of this study be immediately applied to current practice or is more research needed?

Below is the JCS template - but feel free to use your own if you'd like

Background, Guidelines, and Further Reading

Briefly outline the current standard of care - current guidelines(URL) or results of notable trials.

What gaps does this research intend to address to our current understanding of medical therapy?

Methods and Study Design

Type, duration, and location of study

Sample Size and population

Number of patients assigned to each study arm

Baseline Characteristics

Inclusion Criteria

Exclusion Criteria

Interventions

Type of statistical analysis (Intent to treat or harm, etc)

Outcomes (primary, secondary, subgroup analysis, etc)

Funding

Results

Include any statistical values and calculate NNT or NNH if applicable

Primary
Secondary
Subgroups
List any notable unintended adverse effects (note: this can make or break many drugs)

Critique

Your evaluation of this study - strengths and limitations/weaknesses. Clinical impact - can the results of this study be immediately applied to current practice or is more research needed?